Fourth malignancy after treatment of Hodgkin’s lymphoma: a case report

Objective: To evaluate the incidence and treatment of the fourth malignancy in a Hodgkin’s lymphoma (HL) patient. Methods: We reported a HL patient after treatment that developed the second, third, and fourth malignancies (chronic myeloid leukemia, chronic lymphocytic leukemia, and gastric adenocarcinoma) in relatively short time (75 months). The diagnosis was confirmed by pathology, bone marrow morphology, flow cytometry, karyotype and fusion gene examination. Results: He received surgery and chemotherapy. He achieved good response for triple malignancies. After diagnosis with gastric cancer, he orally administered compound tegafur capsule, apatinib and imatinib. Conclusion: The fourth malignancy of HL patient is extremely rare. We recommend a strict follow-up, for HL to detect multiple malignancies.